Fistulizing Epstein-Barr virus-positive plasmablastic lymphoma in an HIV-positive man

J Rangel; R Novoa; C Morrison; D Frank; C Kovarik

doi:10.1111/bjd.14089

Fistulizing Epstein-Barr virus-positive plasmablastic lymphoma in an HIV-positive man

Br J Dermatol. 2016 Feb;174(2):398-401. doi: 10.1111/bjd.14089. Epub 2015 Nov 17.

Authors

J Rangel¹, R Novoa², C Morrison³, D Frank⁴, C Kovarik^{4

5}

Affiliations

¹ Kaiser Permanente, Department of Dermatology, Sacramento, CA, U.S.A.
² Stanford University, Department of Pathology, Department of Dermatology, Stanford, CA, U.S.A.
³ Baylor College of Medicine, Department of Surgery, Houston, TX, U.S.A.
⁴ Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, U.S.A.
⁵ Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, U.S.A.

PMID: 26286218
DOI: 10.1111/bjd.14089

Abstract

Plasmablastic lymphoma (PBL) is an unusual subtype of non-Hodgkin lymphoma recently classified as a diffuse immunoblastic lymphoma with a plasma-cell immunophenotype. Originally described in the oral cavity of HIV-positive patients, it has also been recognized to occur rarely at other sites. We describe a previously unreported fistulizing presentation of Epstein-Barr virus (EBV)-positive PBL, reviewing its association with HIV-1 infection and its importance as an AIDS-defining malignancy.

Publication types

Case Reports

MeSH terms

AIDS-Related Opportunistic Infections / pathology
Anus Neoplasms / pathology*
Anus Neoplasms / virology
Biopsy
Epstein-Barr Virus Infections / pathology*
HIV Seropositivity*
Herpesvirus 4, Human
Humans
Male
Middle Aged
Plasmablastic Lymphoma / pathology*
Plasmablastic Lymphoma / virology
Rectal Fistula / pathology*
Rectal Fistula / virology