Rapid 3D Extrusion of Synthetic Tumor Microenvironments

Adv Mater. 2015 Oct 7;27(37):5512-7. doi: 10.1002/adma.201501729. Epub 2015 Aug 18.

Abstract

The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

Keywords: microfluidics; patterned hydrogels; tissue engineering; tumor microenvironments.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / physiopathology
  • Alginates / chemical synthesis
  • Alginates / chemistry
  • Animals
  • Biomimetic Materials / chemical synthesis
  • Biomimetic Materials / chemistry
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / physiopathology
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Cell Movement / physiology
  • Cell Survival / drug effects
  • Cell Survival / physiology
  • Coculture Techniques
  • Equipment Design
  • Glucuronic Acid / chemical synthesis
  • Glucuronic Acid / chemistry
  • Hexuronic Acids / chemical synthesis
  • Hexuronic Acids / chemistry
  • Humans
  • Hydrogels / chemical synthesis
  • Hydrogels / chemistry
  • Lab-On-A-Chip Devices
  • Macrophages / drug effects
  • Macrophages / physiology
  • Mice
  • Microfluidics / instrumentation
  • Microfluidics / methods*
  • Tissue Scaffolds*
  • Tumor Microenvironment / drug effects*
  • Tumor Microenvironment / physiology*

Substances

  • Alginates
  • Hexuronic Acids
  • Hydrogels
  • Glucuronic Acid