The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity

Placenta. 2015 Oct;36(10):1204-6. doi: 10.1016/j.placenta.2015.07.132. Epub 2015 Aug 6.

Abstract

Toll-like receptor (TLR)-regulated protein kinases and inflammatory cytokines were activated in fetal vascular smooth muscle cells (VSMC) treated with palmitate. Tumor necrosis factor (TNFα) and interleukin-6 (IL6) were increased and correlated with expression of TLRs in the labyrinth placentae of high fat (HF)-fed rats with increased plasma lipids and visceral adiposity. Thus, local induction of TLR signaling via saturated fatty acids (SFA) may in part contribute to placental inflammation in diet-induced maternal obesity.

Keywords: Maternal obesity; Placental inflammation; Toll-like receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diet, High-Fat / adverse effects
  • Female
  • Inflammation / etiology
  • Inflammation / metabolism
  • Interleukin-6 / metabolism
  • Myocytes, Smooth Muscle / metabolism
  • Obesity / etiology
  • Obesity / metabolism*
  • Palmitates / adverse effects
  • Placenta / metabolism*
  • Pregnancy
  • Pregnancy Complications / etiology
  • Pregnancy Complications / metabolism*
  • Random Allocation
  • Rats
  • Toll-Like Receptors / metabolism*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Interleukin-6
  • Palmitates
  • Toll-Like Receptors
  • Tumor Necrosis Factor-alpha