Dietary glycemia as a determinant of health and longevity

Abstract

The role of diet in extending lifespan and healthspan has been the subject of much research and debate. Our recent epidemiological and in vivo data suggest that carbohydrate quality can be a major determinant in prolonging eye health. Additionally, excessive carbohydrate intake can contribute to the exacerbation of many different diseases. The metabolic diversity of the tissues that are affected by excessive carbohydrate intake suggests that dietary carbohydrate quality may affect cellular homeostasis.

Keywords: Autophagy; Eye disease; Glycation; Glycemic index; Proteasome; Ubiquitin.