Objective: To investigate the effect of different pH on rectum permeability of chlorogenic acid and geniposide.
Method: Four kinds of Reduning suppositories of different pH were separated and put into the rectum to study the suppositories in vitro and the content of chlorogenic acid and geniposide samples was determined by HPLC to calculate the permeation in 24 hours.
Result: With increase of pH within 2.5-7.4, the steady state flux of chlorogenic acid was increased, but the steady state flux of geniposidesamples was steady.
Conclusion: Adjusted the pH can increase the rectum permeability of active ingredients in Reduning auppositories.