[METHOD FOR DETERMINING EROSIVE LESIONS OF THE GASTRIC MUCOUSA IN CHILDREN WITH JUVENILE ARTHRITIS]

Eksp Klin Gastroenterol. 2015:(1):17-20.
[Article in Russian]

Abstract

To detect the clinical diagnostic criteria for non-invasive diagnosis of erosive gastritis in children with juvenile arthritis have been studied the 92 children aged 9 to 16 years (mean age-13,9 ± 2,3 years) with verified diagnosis of juvenile arthritis, of whom 10 had erosive gastritis (group 1) and 82 without erosions (group 2). A comparison of the groups on 23 grounds by analysis of contingency tables and the subsequent discriminant analysis, has developed a new non-invasive method for determining the erosive lesions of the mucous membrane of the stomach in children with juvenile arthritis, including a score of history, complaints and the results of laboratory studies the level of the G-17, pepsinogen I, pepsinogen II, and the ratio of pepsinogen I to pepsinogen II, the presence of autoantibodies to the H+, K+/ATPase of the parietal cells of the stomach, the test for occult blood "Colon View Hb and Hb/Hp". Developed a diagnostic table, including 11 features with scores each. The total score 27 or higher allows a high degree of probability to determine the erosive lesions of the gastric mucosa in children with juvenile arthritis.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adolescent
  • Arthritis, Juvenile* / blood
  • Arthritis, Juvenile* / complications
  • Arthritis, Juvenile* / diagnosis
  • Arthritis, Juvenile* / pathology
  • Autoantibodies / blood*
  • Child
  • Female
  • Gastric Mucosa* / metabolism
  • Gastric Mucosa* / pathology
  • Gastrins / blood*
  • Gastritis* / blood
  • Gastritis* / diagnosis
  • Gastritis* / etiology
  • Gastritis* / pathology
  • Humans
  • Male
  • Pepsinogen A / blood*
  • Pepsinogen C / blood*

Substances

  • Autoantibodies
  • Gastrins
  • gastrin 17
  • Pepsinogen C
  • Pepsinogen A