Crystal structure of 5-(1-benzo-furan-2-yl)-3-(4-methyl-phen-yl)-4,5-di-hydro-1,2-oxazol-5-ol

A J Ravi; A C Vinayaka; S Jeyaseelan; M P Sadashiva; H C Devarajegowda

doi:10.1107/S2056989015011263

Crystal structure of 5-(1-benzo-furan-2-yl)-3-(4-methyl-phen-yl)-4,5-di-hydro-1,2-oxazol-5-ol

Acta Crystallogr E Crystallogr Commun. 2015 Jun 17;71(Pt 7):o492-3. doi: 10.1107/S2056989015011263. eCollection 2015 Jul 1.

Authors

A J Ravi¹, A C Vinayaka², S Jeyaseelan³, M P Sadashiva², H C Devarajegowda¹

Affiliations

¹ Department of Physics, Yuvaraja's College (Constituent College), University of Mysore, Mysore 570 005, Karnataka, India.
² Department of Studies in Chemistry, Manasagangotri, University of Mysore, Mysore 570 006, India.
³ Department of Physics, St. Philomena's College, Mysore, India.

Abstract

In the title compound, C18H15NO3, the isoxazole moiety adopts a shallow envelope conformation, with the C atom bearing the OH group displaced by 0.148 (1) Å from the mean plane through the other four atoms. The mean plane of this ring (all atoms) subtends dihedral angles of 87.19 (6) and 15.51 (7)° with the benzo-furan ring system (r.m.s. deviation = 0.007 Å) and the 4-methylphenyl ring, respectively. In the crystal, mol-ecules are linked by O-H⋯N hydrogen bonds, generating [001] C(5) chains, with adjacent mol-ecules in the chain related by c-glide symmetry. Weak C-H⋯O inter-actions link the chains into a three-dimensional network.

Keywords: 1,2-oxazole; alcohol; benzofuran; biological properties; crystal structure; pharmaceutical properties.