Predictors of intrahepatic cholangiocarcinoma in cirrhotic patients scanned by gadobenate dimeglumine-enhanced magnetic resonance imaging: diagnostic accuracy and confidence

Clin Imaging. 2015 Nov-Dec;39(6):1032-8. doi: 10.1016/j.clinimag.2015.06.013. Epub 2015 Jul 17.

Abstract

Objective: To identify predictors of intrahepatic cholangiocarcinoma in cirrhotic patients scanned by gadobenate dimeglumine (Gd-BOPTA)-enhanced magnetic resonance (MR) imaging.

Methods: Fifty cirrhotic patients with 120 nodules, including 10 mass-forming intrahepatic cholangiocarcinomas and two combined hepatocellular carcinoma-cholangiocarcinomas, were scanned by Gd-BOPTA-enhanced MR imaging.

Results: T1 hypointensity [odds ratio (OR), 20.12], peripheral hyperintense rim at hepatic arterial phase (OR, 13.5), and iso-hyperintensity at hepatobiliary phase (OR 21.32) were found to be independent predictors of intrahepatic cholangiocarcinoma.

Conclusions: T1 hypointensity, peripheral hyperintense rim at hepatic arterial phase, and iso-hyperintensity at hepatobiliary phase are independent predictors of intrahepatic cholangiocarcinoma diagnosis in patients with liver cirrhosis.

Keywords: Cholangiocarcinoma; Fibrosis; Hepatocellular; Logistic models; Magnetic resonance imaging.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bile Duct Neoplasms / complications
  • Bile Duct Neoplasms / pathology*
  • Bile Ducts, Intrahepatic / pathology*
  • Carcinoma, Hepatocellular / complications
  • Carcinoma, Hepatocellular / pathology
  • Case-Control Studies
  • Cholangiocarcinoma / complications
  • Cholangiocarcinoma / pathology*
  • Contrast Media
  • Female
  • Humans
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / pathology*
  • Liver Neoplasms / complications
  • Liver Neoplasms / pathology
  • Magnetic Resonance Imaging / methods*
  • Male
  • Meglumine / analogs & derivatives
  • Middle Aged
  • Organometallic Compounds
  • Retrospective Studies
  • Sensitivity and Specificity

Substances

  • Contrast Media
  • Organometallic Compounds
  • gadobenic acid
  • Meglumine