We describe the case of a woman with McCune-Albright syndrome who had a pathological bone fracture while being treated with an oral contraceptive. In this syndrome the bone lesions contain estrogen and progesterone receptors. The possibility of progression of the bone lesions during pregnancy is well-known. We judge the use of oral contraceptives to be dangerous in this syndrome; the affected women must be orientated towards alternative contraceptive methods.
PIP: The authors describe the case of a woman with McCune-Albright syndrome who suffered a pathological bone fracture while being treated with an oral contraceptive (OC). In this syndrome, the bone lesions constrain both estrogen and progesterone receptors. The possibility of progression of these bone lesions during pregnancy is well-documented. The authors judge the use of OCs to be dangerous in this syndrome, and thus, the women affected by it must be directed to alternative contraceptive methods.