Genetics of Canine Primary Glaucomas

András M Komáromy; Simon M Petersen-Jones

doi:10.1016/j.cvsm.2015.06.003

Genetics of Canine Primary Glaucomas

Vet Clin North Am Small Anim Pract. 2015 Nov;45(6):1159-82, v. doi: 10.1016/j.cvsm.2015.06.003. Epub 2015 Aug 13.

Authors

András M Komáromy¹, Simon M Petersen-Jones²

Affiliations

¹ Department of Small Animal Clinical Sciences, Veterinary Medical Center, College of Veterinary Medicine, Michigan State University, 736 Wilson Road, Room D-208, East Lansing, MI 48824, USA. Electronic address: komaromy@cvm.msu.edu.
² Department of Small Animal Clinical Sciences, Veterinary Medical Center, College of Veterinary Medicine, Michigan State University, 736 Wilson Road, Room D-208, East Lansing, MI 48824, USA.

PMID: 26277300
DOI: 10.1016/j.cvsm.2015.06.003

Abstract

Primary glaucomas are a leading cause of incurable vision loss in dogs. Based on their specific breed predilection, a genetic cause is suspected to be responsible, and affected dogs should be excluded from breeding. Despite the high prevalence of primary glaucomas in dogs, their genetics have been studied in only a small number of breeds. The identification of canine glaucoma disease genes, and the development of genetic tests, will help to avoid the breeding of affected dogs in the future and will allow for earlier diagnosis and potentially more effective therapy.

Keywords: ADAMTS10; ADAMTS17; Canine; Closed-angle; Genetics; Glaucoma; Lens luxation; Open-angle.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Dog Diseases / genetics*
Dogs
Genetic Predisposition to Disease*
Glaucoma / genetics
Glaucoma / veterinary*