Clinical potential of boron neutron capture therapy for locally recurrent inoperable previously irradiated head and neck cancer

Diana Lim; Daniel S C Quah; Michelle Leech; Laure Marignol

doi:10.1016/j.apradiso.2015.07.044

Clinical potential of boron neutron capture therapy for locally recurrent inoperable previously irradiated head and neck cancer

Appl Radiat Isot. 2015 Dec:106:237-41. doi: 10.1016/j.apradiso.2015.07.044. Epub 2015 Jul 28.

Authors

Diana Lim¹, Daniel S C Quah², Michelle Leech¹, Laure Marignol³

Affiliations

¹ Applied Radiation Therapy Trinity, Discipline of Radiation Therapy, School of Medicine, Trinity Centre for Health sciences, Trinity College Dublin, Ireland.
² Department of Radiation Oncology, National Cancer Centre, Singapore.
³ Applied Radiation Therapy Trinity, Discipline of Radiation Therapy, School of Medicine, Trinity Centre for Health sciences, Trinity College Dublin, Ireland. Electronic address: marignol@tcd.ie.

PMID: 26277052
DOI: 10.1016/j.apradiso.2015.07.044

Abstract

This review compares the safety and efficacy of boron neutron capture therapy (BNCT) in the treatment of previously irradiated, inoperable locoregional recurrent HNC patients and compares BNCT against the standard treatment of platinum-based chemotherapy. Our analysis of published clinical trials highlights efficacy of BNCT associated with mild side effects. However, the use of BNCT should be explored in stratified randomised trials.

Publication types

Review

MeSH terms

Adult
Aged
Boron Neutron Capture Therapy*
Head and Neck Neoplasms / pathology
Head and Neck Neoplasms / radiotherapy*
Humans
Middle Aged
Neoplasm Recurrence, Local