Multiple trials were conducted from 2006 to 2014 in an attempt to validate aerial spray efficacy at altitudes conducive to night spray operations using night vision goggles (NVGs). Higher altitude application of pesticide (more than 400 ft (121.9 m) above ground level (AGL)) suggested that effective vector control might be possible under ideal meteorological conditions. A series of lower altitude daytime applications (300 ft (91.4 m) AGL) demonstrated effective and repeatable mortality of target sentinel insects more than 5,000 ft (1,524 m) downwind, and control of natural vector populations. From these results we believe further pursuit of aerial night applications of pesticide using NVGs at 300 ft (91.4 m) AGL by this group is warranted.