An AAA+ ATPase Clamshell Targets Transposition

Chi-Lin Tsai; Gareth J Williams; J Jefferson P Perry; John A Tainer

doi:10.1016/j.cell.2015.07.050

An AAA+ ATPase Clamshell Targets Transposition

Cell. 2015 Aug 13;162(4):701-3. doi: 10.1016/j.cell.2015.07.050.

Authors

Chi-Lin Tsai¹, Gareth J Williams¹, J Jefferson P Perry², John A Tainer³

Affiliations

¹ Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
² Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA.
³ Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: jatainer@lbl.gov.

Abstract

DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Bacteria / genetics*
Bacteria / metabolism*
DNA Transposable Elements*

Substances

DNA Transposable Elements

Abstract

Publication types

MeSH terms

Substances

Grants and funding