Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor

Masutaka Furue; Gaku Tsuji; Chikage Mitoma; Takeshi Nakahara; Takahito Chiba; Saori Morino-Koga; Hiroshi Uchi

doi:10.1016/j.jdermsci.2015.07.011

Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor

J Dermatol Sci. 2015 Nov;80(2):83-8. doi: 10.1016/j.jdermsci.2015.07.011. Epub 2015 Jul 26.

Authors

Masutaka Furue¹, Gaku Tsuji², Chikage Mitoma², Takeshi Nakahara³, Takahito Chiba⁴, Saori Morino-Koga⁵, Hiroshi Uchi⁴

Affiliations

¹ Department of Dermatology, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Division of Skin Surface Sensing, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan. Electronic address: furue@dermatol.med.kyushu-u.ac.jp.
² Department of Dermatology, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.
³ Department of Dermatology, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Division of Skin Surface Sensing, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.
⁴ Department of Dermatology, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.
⁵ Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.

PMID: 26276439
DOI: 10.1016/j.jdermsci.2015.07.011

Abstract

Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.

Keywords: Aryl hydrocarbon receptor; Barrier protein; Filaggrin; Nuclear factor-erythroid 2-related factor-2; Reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Coal Tar / toxicity
Environmental Pollutants / toxicity
Filaggrin Proteins
Gene Expression Regulation
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Intermediate Filament Proteins / genetics
Intermediate Filament Proteins / metabolism*
Malassezia / metabolism
NF-E2-Related Factor 2 / metabolism
Oxidative Stress
Permeability
Phytochemicals / toxicity
Polychlorinated Dibenzodioxins / toxicity
Receptors, Aryl Hydrocarbon / agonists
Receptors, Aryl Hydrocarbon / genetics
Receptors, Aryl Hydrocarbon / metabolism*
Skin / drug effects
Skin / metabolism*
Skin / radiation effects
Transcription, Genetic
Ultraviolet Rays

Substances

Environmental Pollutants
FLG protein, human
Filaggrin Proteins
HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit
Intermediate Filament Proteins
NF-E2-Related Factor 2
Phytochemicals
Polychlorinated Dibenzodioxins
Receptors, Aryl Hydrocarbon
Coal Tar