Facile Enzymatic Synthesis of Ketoses

Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12654-8. doi: 10.1002/anie.201505714. Epub 2015 Aug 14.

Abstract

Studies of rare ketoses have been hampered by a lack of efficient preparation methods. A convenient, efficient, and cost-effective platform for the facile synthesis of ketoses is described. This method enables the preparation of difficult-to-access ketopentoses and ketohexoses from common and inexpensive starting materials with high yield and purity and without the need for a tedious isomer separation step.

Keywords: enzymatic synthesis; ketoses; one-pot reactions; phosphorylation; synthetic methods.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocatalysis
  • Chemistry Techniques, Synthetic / economics
  • Chemistry Techniques, Synthetic / methods
  • Fructokinases / metabolism
  • Humans
  • Isomerism
  • Ketoses / chemical synthesis*
  • Ketoses / chemistry
  • Ketoses / metabolism*
  • Phosphorylation
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism
  • Protein Biosynthesis
  • Thermotoga maritima / enzymology

Substances

  • Ketoses
  • Fructokinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • rhamnulokinase