Highly selective two-photon imaging of cysteine in cancerous cells and tissues

Chem Commun (Camb). 2015 Oct 1;51(76):14401-4. doi: 10.1039/c5cc06038a. Epub 2015 Aug 14.

Abstract

Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this probe for the imaging of live cancerous cells and thick tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cysteine / analysis*
  • Fluorescent Dyes / chemistry*
  • Glutathione / analysis
  • HeLa Cells
  • Hep G2 Cells
  • Homocysteine / analysis
  • Humans
  • Mice
  • Microscopy, Fluorescence, Multiphoton / methods
  • Neoplasms / chemistry*
  • Neoplasms / pathology*
  • Optical Imaging / methods*
  • Spectrometry, Fluorescence

Substances

  • Fluorescent Dyes
  • Homocysteine
  • Glutathione
  • Cysteine