Histiocytoid neutrophilic dermatitis, an unusual histopathology in neonatal lupus erythematosus

Panitta Sitthinamsuwan; Rattanavalai Nitiyarom; Manasmon Chairatchaneeboon; Wanee Wisuthsarewong

doi:10.1111/cup.12594

Histiocytoid neutrophilic dermatitis, an unusual histopathology in neonatal lupus erythematosus

J Cutan Pathol. 2015 Dec;42(12):996-999. doi: 10.1111/cup.12594. Epub 2015 Oct 9.

Authors

Panitta Sitthinamsuwan¹, Rattanavalai Nitiyarom², Manasmon Chairatchaneeboon³, Wanee Wisuthsarewong²

Affiliations

¹ Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
² Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
³ Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

PMID: 26269318
DOI: 10.1111/cup.12594

Abstract

The authors reported histiocytoid neutrophilic dermatitis in neonatal lupus erythematosus (NLE). One-month-old male infant presented with annular erythematous plaques at the face and trunk. Serologic studies revealed positive anti-ribonuclear protein antibodies (RNP) and antinuclear antibodies (ANA). Histopathology showed predominant myeloid lineage mononuclear cells admixed with segmented neutrophils. This finding is uncommon in cutaneous NLE. Cutaneous NLE and LE should be included in the differential diagnosis of histiocytoid neutrophilic dermatitis. Additional immunohistochemistry studies with clinical and serologic correlations are important to differentiate histiocytoid neutrophilic dermatitis from the other diagnoses, especially leukemic cutis in young patients.

Keywords: SLE; dermatopathology; histopathology.

Publication types

Case Reports