A critical role of toll-like receptor 2 (TLR2) and its' in vivo ligands in radio-resistance

Sci Rep. 2015 Aug 13:5:13004. doi: 10.1038/srep13004.

Abstract

The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(-/-)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(-/-) mice. The cause of death in TLR2(-/-) mice may be severe and persistent bone marrow cell loss. Injection of the TLR2 agonist Pam3CSK4 into wild type (WT) mice induced radio-resistance. Myd88(-/-) mice were more susceptible to radiation. In conclusion, our data indicate that, similar to TLR4, TLR2 plays a critical role in radio-resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow Cells / pathology
  • Bone Marrow Cells / radiation effects*
  • Humans
  • Lipopeptides / administration & dosage
  • Mice
  • Mice, Knockout
  • Radiation Tolerance / drug effects
  • Radiation Tolerance / genetics*
  • Toll-Like Receptor 2 / agonists
  • Toll-Like Receptor 2 / genetics*

Substances

  • Lipopeptides
  • Pam(3)CSK(4) peptide
  • TLR2 protein, human
  • Toll-Like Receptor 2