Three New Isomeric Indole Alkaloids from Nauclea officinalis

Chem Biodivers. 2015 Aug;12(8):1256-62. doi: 10.1002/cbdv.201400289.

Abstract

Three new isomeric monoterpene indole alkaloids, naucleofficines I-III (1-3, resp.) were isolated from the stems (with bark) of Nauclea officinalis. Their structures were elucidated on the basis of spectroscopic methods and single-crystal diffraction analyses. The cytotoxic activities of 1-3 against human colon cancer, human gastric cancer, and human hepatoma cells were also investigated.

Keywords: Cytotoxic activity; Monoterpene indole alkaloids; Nauclea officinalis; Naucleofficines I - III.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Crystallography, X-Ray
  • Humans
  • Indole Alkaloids / chemistry*
  • Indole Alkaloids / isolation & purification
  • Indole Alkaloids / pharmacology*
  • Models, Molecular
  • Neoplasms / drug therapy
  • Plant Stems / chemistry
  • Rubiaceae / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Indole Alkaloids