Lupane- and Friedelane-Type Triterpenoids from Celastrus stylosus

You-Min Ying; Cui-Yu Li; Yan Chen; Jia-Gui Xiang; Ling Fang; Jian-Biao Yao; Fa-Song Wang; Ru-Wei Wang; Wei-Guang Shan; Zha-Jun Zhan

doi:10.1002/cbdv.201400269

Lupane- and Friedelane-Type Triterpenoids from Celastrus stylosus

Chem Biodivers. 2015 Aug;12(8):1222-8. doi: 10.1002/cbdv.201400269.

Authors

You-Min Ying^{1

2}, Cui-Yu Li¹, Yan Chen¹, Jia-Gui Xiang¹, Ling Fang², Jian-Biao Yao², Fa-Song Wang³, Ru-Wei Wang², Wei-Guang Shan⁴, Zha-Jun Zhan⁵

Affiliations

¹ College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)).
² Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P. R. China.
³ Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province and College of Chemistry and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, P. R. China.
⁴ College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)). tianranyaowu@zjut.edu.cn.
⁵ College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)). zjnpr@zjut.edu.cn.

PMID: 26265574
DOI: 10.1002/cbdv.201400269

Abstract

Two new triterpenoids, 30-hydroxylup-20(29)-ene 3β-caffeate (1) and 24-nor-friedelan-6α,10-dihydroxy-1,2-dioxo-4,7-dien-29-oic acid (2), together with eight known compounds 3-10, were isolated from the roots of Celastrus stylosus. The structures of these compounds were elucidated on the basis of spectroscopic analyses. To the best of our knowledge, this represents the first study on the chemical constituents of C. stylosus. The antiproliferative activities of the triterpenoids against six human cancer cell lines (PANC-1, A549, PC-3, HepG2, SGC-7901, and HCCLM3) were evaluated. Compounds 3, 4, and 10 exhibited comparable activities against PC-3 and HCCLM3 cell lines as the positive control taxol.

Keywords: Antiproliferative activities; Celastrus stylosus; Friedelanes; Lupanes; Triterpenoids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Celastrus / chemistry*
Cell Line, Tumor
Cell Proliferation / drug effects
Humans
Neoplasms / drug therapy
Neoplasms / pathology
Triterpenes / chemistry*
Triterpenes / isolation & purification
Triterpenes / pharmacology*

Substances

Antineoplastic Agents, Phytogenic
Triterpenes
friedelane
lupane