Well-differentiated mucinous uterine adenocarcinoma predominantly diagnosed as adenoma malignum: a case report with an immunohistochemical analysis

Int J Clin Exp Pathol. 2015 Jun 1;8(6):7600-4. eCollection 2015.

Abstract

Adenoma malignum (AM), also referred to as "minimal deviation adenocarcinoma", is an extremely uncommon variant of highly-differentiated adenocarcinoma of the uterine cervix. The study presented herein describes a case of uterine AM found out after hysteroscopy. An early-stage, well-differentiated mucinous uterine adenocarcinoma was diagnosed post-operatively. A subsequent immunohistochemical assessment of a panel of antibodies was applied, in order to distinguish between female genital tract malignancies.

Keywords: Adenoma malignum; immunohistochemistry; uterine cancer.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma, Mucinous / chemistry*
  • Adenocarcinoma, Mucinous / pathology
  • Adenocarcinoma, Mucinous / surgery
  • Biomarkers, Tumor / analysis*
  • Cell Differentiation*
  • Female
  • Humans
  • Immunohistochemistry*
  • Middle Aged
  • Neoplasm Staging
  • Predictive Value of Tests
  • Treatment Outcome
  • Uterine Neoplasms / chemistry*
  • Uterine Neoplasms / pathology
  • Uterine Neoplasms / surgery

Substances

  • Biomarkers, Tumor