Cu(II)-Mediated C(sp(2))-H Hydroxylation

Shang-Zheng Sun; Ming Shang; Hong-Li Wang; Hai-Xia Lin; Hui-Xiong Dai; Jin-Quan Yu

doi:10.1021/acs.joc.5b01351

Cu(II)-Mediated C(sp(2))-H Hydroxylation

J Org Chem. 2015 Sep 4;80(17):8843-8. doi: 10.1021/acs.joc.5b01351. Epub 2015 Aug 17.

Authors

Shang-Zheng Sun¹, Ming Shang², Hong-Li Wang², Hai-Xia Lin¹, Hui-Xiong Dai², Jin-Quan Yu^{2

3}

Affiliations

¹ Department of Chemistry, Innovative Drug Research Center, Shanghai University , 99 Shangda Road, Shanghai 200444, China.
² State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
³ Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

PMID: 26259687
DOI: 10.1021/acs.joc.5b01351

Abstract

A Cu(II)-mediated ortho-C-H hydroxylation using a removable directing group has been developed. The reaction exhibits considerable functional group tolerance. The use of O2 as an oxidant is crucial for the reactivity. Water is also found to significantly improve this reaction.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.