Electrochemically triggered release of human insulin from an insulin-impregnated reduced graphene oxide modified electrode

Chem Commun (Camb). 2015 Sep 28;51(75):14167-70. doi: 10.1039/c5cc05539c. Epub 2015 Aug 10.

Abstract

An electrochemical insulin-delivery system based on reduced graphene oxide impregnated with insulin is described. Upon application of a potential pulse of -0.8 V for 30 min, up to 70 ± 4% of human insulin was released into a physiological medium while preserving its biological activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electrochemical Techniques*
  • Electrodes
  • Graphite / chemistry*
  • Humans
  • Insulin / chemistry*
  • Molecular Structure
  • Oxides / chemistry*
  • Particle Size
  • Surface Properties

Substances

  • Insulin
  • Oxides
  • Graphite