Catecholaminergic Polymorphic Ventricular Tachycardia with QT Prolongation

Pacing Clin Electrophysiol. 2015 Dec;38(12):1499-502. doi: 10.1111/pace.12735. Epub 2015 Oct 8.

Abstract

The QT interval in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) is typically normal. However, CPVT patients are sometimes misdiagnosed as concealed long QT syndrome (LQTS), because patients with LQTS also manifest with syncope or sudden death following periods of exertion or extreme emotion. We report a CPVT patient with a pathogenic RyR2 mutation associated with a marked QT prolongation, which normalized after flecainide therapy.

Keywords: bidirectional ventricular tachycardia; catecholaminergic polymorphic ventricular tachycardia; flecainide; long QT syndrome; sudden cardiac death.

Publication types

  • Case Reports

MeSH terms

  • Diagnosis, Differential
  • Electrocardiography / methods*
  • Female
  • Humans
  • Long QT Syndrome / complications*
  • Long QT Syndrome / diagnosis*
  • Tachycardia, Ventricular / complications*
  • Tachycardia, Ventricular / diagnosis*
  • Young Adult

Supplementary concepts

  • Polymorphic catecholergic ventricular tachycardia