Cytosolic BMAL1 moonlights as a translation factor

Alicia K Michael; Hande Asimgil; Carrie L Partch

doi:10.1016/j.tibs.2015.07.006

Cytosolic BMAL1 moonlights as a translation factor

Trends Biochem Sci. 2015 Sep;40(9):489-90. doi: 10.1016/j.tibs.2015.07.006. Epub 2015 Aug 7.

Authors

Alicia K Michael¹, Hande Asimgil¹, Carrie L Partch²

Affiliations

¹ Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
² Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. Electronic address: cpartch@ucsc.edu.

Abstract

It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Lipton et al. now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein synthesis in response to mTOR signaling.

Publication types

Comment

MeSH terms

ARNTL Transcription Factors / metabolism*
Animals
Circadian Clocks*
Ribosomal Protein S6 Kinases, 90-kDa / metabolism*

Substances

ARNTL Transcription Factors
Ribosomal Protein S6 Kinases, 90-kDa

Abstract

Publication types

MeSH terms

Substances

Grants and funding