Abstract
A multicomponent reaction between imines, terminal alkynes, and isothiocyanates in the presence of a catalytic chiral copper-pybox complex proceeds enantioselectively to give enantiopure thiazolidine-2-imines (60-99% ee) via a highly regioselective intramolecular 5-exo-dig hydrothiolation reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Alkynes / chemistry*
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Imines / chemical synthesis*
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Imines / chemistry*
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Isothiocyanates / chemistry*
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Molecular Structure
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Stereoisomerism
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Thiazolidines / chemical synthesis*
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Thiazolidines / chemistry
Substances
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Alkynes
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Imines
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Isothiocyanates
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Thiazolidines