MT-Nanotubes: Lifelines for Stem Cells

Marc Amoyel; Erika A Bach

doi:10.1016/j.stem.2015.07.004

MT-Nanotubes: Lifelines for Stem Cells

Cell Stem Cell. 2015 Aug 6;17(2):133-4. doi: 10.1016/j.stem.2015.07.004.

Authors

Marc Amoyel¹, Erika A Bach²

Affiliations

¹ Department of Biochemistry and Molecular Pharmacology, The Helen L. and Martin S. Kimmel Center for Stem Cell Biology, New York University School of Medicine, 550 First Avenue, MSB 497B, New York, NY 10016, USA.
² Department of Biochemistry and Molecular Pharmacology, The Helen L. and Martin S. Kimmel Center for Stem Cell Biology, New York University School of Medicine, 550 First Avenue, MSB 497B, New York, NY 10016, USA. Electronic address: erika.bach@nyu.edu.

PMID: 26253198
DOI: 10.1016/j.stem.2015.07.004

Abstract

Niche cells produce secreted factors that promote the self-renewal of stem cells in their immediate proximity, but how signaling is restricted to stem cells is not well understood. Inaba et al. (2015) report that microtubule (MT) structures called MT-nanotubes control activation of the primary self-renewal pathway in Drosophila testes.

Publication types

Comment

MeSH terms

Animals
Drosophila melanogaster / cytology*
Male
Microtubules / chemistry*
Microtubules / metabolism*
Nanotubes*
Signal Transduction*
Stem Cell Niche / physiology*
Testis / cytology*

Grants and funding

R01 GM085075/GM/NIGMS NIH HHS/United States