Electrospinning of PEGylated polyamidoamine dendrimer fibers

Donald C Aduba Jr; Jefferson W Overlin; Chad D Frierson; Gary L Bowlin; Hu Yang

doi:10.1016/j.msec.2015.06.025

Electrospinning of PEGylated polyamidoamine dendrimer fibers

Mater Sci Eng C Mater Biol Appl. 2015 Nov 1:56:189-94. doi: 10.1016/j.msec.2015.06.025. Epub 2015 Jun 14.

Authors

Donald C Aduba Jr¹, Jefferson W Overlin¹, Chad D Frierson², Gary L Bowlin³, Hu Yang⁴

Affiliations

¹ Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA.
² Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA.
³ Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA.
⁴ Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address: hyang2@vcu.edu.

Abstract

Polyamidoamine (PAMAM) dendrimers have emerged as an important class of nanostructured materials and have found a broad range of applications. There is also an ongoing effort to synthesize higher-complexity structures using PAMAM dendrimers as enabling building blocks. Herein, we report for the first time the fabrication of electrospun nanocomposite fibers composed of dendrimer derivatives, namely PEGylated PAMAM dendrimers, blended with a small amount of high-molecular-weight polyethylene oxide (PEO). Morphological features and mechanical properties of the resulting dendrimer fiber mats were assessed.

Keywords: Dendrimer; Electrospinning; Fast Fourier transform; Nanofiber; PEGylation.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Dendrimers / chemistry*
Nanocomposites / chemistry*
Polyethylene Glycols / chemistry*

Substances

Dendrimers
PAMAM Starburst
Polyethylene Glycols
polyethylene glycol 1000

Abstract

Publication types

MeSH terms

Substances

Grants and funding