Supporting itch: a new role for astrocytes in chronic itch

Dustin Green; Xinzhong Dong

doi:10.1038/nm.3921

Supporting itch: a new role for astrocytes in chronic itch

Nat Med. 2015 Aug;21(8):841-2. doi: 10.1038/nm.3921.

Authors

Dustin Green¹, Xinzhong Dong²

Affiliations

¹ Department of Neuroscience, Department of Neurosurgery, Department of Dermatology and Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
² Department of Neuroscience, Department of Neurosurgery, Department of Dermatology, Center for Sensory Biology and the Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

PMID: 26248264
PMCID: PMC6053542
DOI: 10.1038/nm.3921

Abstract

A new study shows that astrocytes are involved in the development of chronic itch in a mouse model. This dependent on upregulation of lipocalin 2 (LCN2) by the transcription factor STAT-3 and astrogliosis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Male
Pruritus / etiology*
STAT3 Transcription Factor / physiology*
Spinal Cord Dorsal Horn / pathology*

Substances

STAT3 Transcription Factor

Abstract

Publication types

MeSH terms

Substances

Grants and funding