Current perspectives on the dynamics of antibiotic resistance in different reservoirs

Manuela Caniça; Vera Manageiro; Daniela Jones-Dias; Lurdes Clemente; Eduarda Gomes-Neves; Patrícia Poeta; Elsa Dias; Eugénia Ferreira

doi:10.1016/j.resmic.2015.07.009

Current perspectives on the dynamics of antibiotic resistance in different reservoirs

Res Microbiol. 2015 Sep;166(7):594-600. doi: 10.1016/j.resmic.2015.07.009. Epub 2015 Aug 4.

Authors

Manuela Caniça¹, Vera Manageiro², Daniela Jones-Dias³, Lurdes Clemente⁴, Eduarda Gomes-Neves⁵, Patrícia Poeta⁶, Elsa Dias⁷, Eugénia Ferreira⁸

Affiliations

¹ National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal. Electronic address: manuela.canica@insa.min-saude.pt.
² National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal; Centre for the Studies of Animal Science, Institute of Agrarian and Agri-Food Sciences and Technologies, Oporto University, Oporto, Portugal. Electronic address: vera.manageiro@insa.min-saude.pt.
³ National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal; Centre for the Studies of Animal Science, Institute of Agrarian and Agri-Food Sciences and Technologies, Oporto University, Oporto, Portugal. Electronic address: daniela.dias@insa.min-saude.pt.
⁴ INIAV - Instituto Nacional de Investigação Agrária e Veterinária, Lisbon, Portugal. Electronic address: lurdes.clemente@iniav.pt.
⁵ Centre for the Studies of Animal Science, Institute of Agrarian and Agri-Food Sciences and Technologies, Oporto University, Oporto, Portugal; ICBAS, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Oporto, Portugal. Electronic address: emneves@icbas.up.pt.
⁶ Department of Animal and Veterinary Sciences (CECAV), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal. Electronic address: ppoeta@utad.pt.
⁷ National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal; Centre for the Studies of Animal Science, Institute of Agrarian and Agri-Food Sciences and Technologies, Oporto University, Oporto, Portugal; Department of Environmental Health, National Institute of Health, Lisbon, Portugal. Electronic address: elsa.dias@insa.min-saude.pt.
⁸ National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal. Electronic address: eugenia.ferreira@insa.min-saude.pt.

PMID: 26247891
DOI: 10.1016/j.resmic.2015.07.009

Abstract

Antibiotic resistance consists of a dynamic web. In this review, we describe the path by which different antibiotic residues and antibiotic resistance genes disseminate among relevant reservoirs (human, animal, and environmental settings), evaluating how these events contribute to the current scenario of antibiotic resistance. The relationship between the spread of resistance and the contribution of different genetic elements and events is revisited, exploring examples of the processes by which successful mobile resistance genes spread across different niches. The importance of classic and next generation molecular approaches, as well as action plans and policies which might aid in the fight against antibiotic resistance, are also reviewed.

Keywords: Antibiotics; Dissemination; Mobilome; Reservoirs; Resistome.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bacteria / drug effects*
Bacteria / genetics
Bacterial Infections / microbiology*
Bacterial Infections / veterinary*
Drug Resistance, Bacterial*
Environmental Microbiology*
Gene Transfer, Horizontal
Genes, Bacterial
Humans
Interspersed Repetitive Sequences