Diketopyrrolopyrrole-Based Semiconducting Polymer Nanoparticles for In Vivo Photoacoustic Imaging

Kanyi Pu; Jianguo Mei; Jesse V Jokerst; Guosong Hong; Alexander L Antaris; Niladri Chattopadhyay; Adam J Shuhendler; Tadanori Kurosawa; Yan Zhou; Sanjiv S Gambhir; Zhenan Bao; Jianghong Rao

doi:10.1002/adma.201502285

Diketopyrrolopyrrole-Based Semiconducting Polymer Nanoparticles for In Vivo Photoacoustic Imaging

Adv Mater. 2015 Sep 16;27(35):5184-90. doi: 10.1002/adma.201502285. Epub 2015 Aug 6.

Authors

Affiliations

¹ Molecular Imaging Program at Stanford Department of Radiology, School of Medicine, Stanford University, CA, 94305, USA.
² Department of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.
³ Department of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.
⁴ Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
⁵ Department of Bioengineering, Stanford, CA, 94305, USA.

Abstract

Diketopyrrolopyrrole-based semiconducting polymer nanoparticles with high photostability and strong photoacoustic brightness are designed and synthesized, which results in 5.3-fold photoacoustic signal enhancement in tumor xenografts after systemic administration.

Keywords: contrast agent; photoacoustic imaging; photothermal imaging; semiconducting polymer nanoparticles; tumor imaging.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Transformation, Neoplastic
HeLa Cells
Humans
Ketones / chemistry*
Mice
Models, Molecular
Molecular Conformation
Nanoparticles / chemistry*
Photoacoustic Techniques / methods*
Polymers / chemistry*
Pyrroles / chemistry*
Semiconductors*

Substances

Ketones
Polymers
Pyrroles
diketopyrrolopyrrole dye

Abstract

Publication types

MeSH terms

Substances

Grants and funding