Excessive regurgitation and suspected reflux disease are increasingly leading to referrals to hospital and pharmacologic therapies. Reflux (or regurgitation) as such is a physiological phenomenon in infants and does not require treatment, unless it is associated with other symptoms indicating a disease. The reflux symptoms in infants will nearly always improve spontaneously. Proton pump inhibitors have been found to be no more efficient than placebo in the treatment of reflux symptoms in infants. Breast milk should not be exchanged for a special infant formula due to reflux. The prognosis of reflux symptoms of a basically healthy infant is almost invariably excellent.