NNMT: A Bad Actor in Fat Makes Good in Liver

Samuel A J Trammell; Charles Brenner

doi:10.1016/j.cmet.2015.07.017

NNMT: A Bad Actor in Fat Makes Good in Liver

Cell Metab. 2015 Aug 4;22(2):200-1. doi: 10.1016/j.cmet.2015.07.017.

Authors

Samuel A J Trammell¹, Charles Brenner²

Affiliations

¹ Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
² Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Obesity Research & Education Initiative, Carver College of Medicine, University of Iowa, Iowa City, IA 52242. Electronic address: charles-brenner@uiowa.edu.

Abstract

High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.

Publication types

Comment

MeSH terms

Animals
Female
Humans
Liver / metabolism*
Male
Nicotinamide N-Methyltransferase / physiology*
Sirtuin 1 / physiology*

Substances

Nicotinamide N-Methyltransferase
Sirtuin 1

Abstract

Publication types

MeSH terms

Substances

Grants and funding