Abstract
A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the resulting donor-acceptor cyclopropanes and subsequent in situ reduction of enamine (imine) intermediates.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amides / chemical synthesis*
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Amines / chemistry*
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Cyclopropanes / chemistry*
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Molecular Structure
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Stereoisomerism
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gamma-Aminobutyric Acid / chemistry*
Substances
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Amides
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Amines
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Cyclopropanes
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gamma-Aminobutyric Acid
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cyclopropene