CD7 aberrant expression led to a lineage switch at relapsed childhood acute pre-B lymphoblastic leukemia

Med Mol Morphol. 2016 Mar;49(1):53-6. doi: 10.1007/s00795-015-0117-0. Epub 2015 Aug 5.

Abstract

Immunophenotypic changes and lineage switch between diagnosis and relapse in acute lymphoblastic leukemia are uncommon and accompanied by poor outcomes. In this report, a 12-year-old boy with diagnosis of pre-B ALL with an aberrant expression of CD 7 is described. Patient was treated with the ALL-BFM 2000 protocol and suffered an episode of relapse with a lineage switch from pre-B ALL to T cell ALL. This report concludes that presence of aberrant expression of CD7 at diagnosis of pre-B ALL can have prognostic value of lineage switch to T cell ALL at relapse.

Keywords: Lineage switch; Lymphoblastic leukemia; Neoplasm antigens; Recurrence.

Publication types

  • Case Reports

MeSH terms

  • Antigens, CD7 / metabolism*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Humans
  • Male
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Recurrence

Substances

  • Antigens, CD7