Abstract
This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemical synthesis*
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Antioxidants / pharmacology*
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Brain Ischemia / drug therapy*
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Cell Death / drug effects
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Cells, Cultured
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Cholesterol / analogs & derivatives*
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Cholesterol / chemical synthesis
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Cholesterol / pharmacology
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Ischemic Attack, Transient / drug therapy
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Ischemic Attack, Transient / psychology
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Nervous System Diseases / prevention & control
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Nervous System Diseases / psychology
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Neurons / drug effects
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Neuroprotective Agents / chemical synthesis*
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Neuroprotective Agents / pharmacology*
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Nitrogen Oxides / chemical synthesis*
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Nitrogen Oxides / pharmacology*
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Rats
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Reactive Oxygen Species
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Reperfusion Injury / drug therapy
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Stroke / drug therapy*
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Structure-Activity Relationship
Substances
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Antioxidants
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Neuroprotective Agents
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Nitrogen Oxides
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Reactive Oxygen Species
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cholesteronitrone
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nitrones
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Cholesterol