Paeoveitols A-E from Paeonia veitchii

Fitoterapia. 2015 Oct:106:36-40. doi: 10.1016/j.fitote.2015.07.015. Epub 2015 Aug 1.

Abstract

Paeoveitols A-E (1-5), involving three monoterpenes and two benzofuran constituents, were isolated from Paeonia veitchii. Their structures were determined based on extensive spectral analyses (IR, UV, MS, 1D and 2D NMR), and the absolute configuration of compound 1 was confirmed by single-crystal X-ray diffraction. By the agitating human melatonin receptor 1 (MT1) assay on HEK293 cell line in vitro, compound 4 showed weak activity with the agitation rate of 22.52% at the concentration of 1.79 mM.

Keywords: Benzofurans; Monoterpenes; Paeonia veitchii; Paeoniaceae; Paeoveitols A–E.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzofurans / chemistry
  • Benzofurans / isolation & purification
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • HEK293 Cells
  • Humans
  • Molecular Structure
  • Monoterpenes / chemistry
  • Monoterpenes / isolation & purification
  • Paeonia / chemistry*
  • Plant Roots / chemistry

Substances

  • Benzofurans
  • Diterpenes
  • Monoterpenes
  • paeoveitol
  • benzofuran