Screening and Invasive Testing in Twins

Giovanni Monni; Ambra Iuculano; Maria Angelica Zoppi

doi:10.3390/jcm3030865

Screening and Invasive Testing in Twins

J Clin Med. 2014 Jul 29;3(3):865-82. doi: 10.3390/jcm3030865.

Authors

Giovanni Monni¹, Ambra Iuculano², Maria Angelica Zoppi³

Affiliations

¹ Department of Obstetrics and Gynecology, Prenatal and Preimplantation Genetic Diagnosis, Fetal Therapy, Ospedale Microcitemico, via Jenner, 09121 Cagliari, Italy. prenatalmonni@tiscali.it.
² Department of Obstetrics and Gynecology, Prenatal and Preimplantation Genetic Diagnosis, Fetal Therapy, Ospedale Microcitemico, via Jenner, 09121 Cagliari, Italy. ambraiuc@tiscali.it.
³ Department of Obstetrics and Gynecology, Prenatal and Preimplantation Genetic Diagnosis, Fetal Therapy, Ospedale Microcitemico, via Jenner, 09121 Cagliari, Italy. angelica.zoppi@tiscali.it.

Abstract

Prenatal screening and testing for trisomy 21 in twin pregnancies poses a number of challenges: the exact estimate of the a priori risk of trisomy 21, the choice of prenatal screening test and/or invasive techniques to employ for the diagnosis and the impact of the result on the options of treatment in case of discordant results within a twin pair or among multiples. These different aspects are discussed below while recognizing that many issues remain unresolved.

Keywords: invasive diagnosis; screening; therapy; twins.

Publication types

Review