Male-mediated F1 effects in mice exposed to bisphenol A, either alone or in combination with X-irradiation

Mutat Res Genet Toxicol Environ Mutagen. 2015 Aug:789-790:36-45. doi: 10.1016/j.mrgentox.2015.06.015. Epub 2015 Jun 30.

Abstract

We investigated the possible transmission of heritable changes via the sperm, following preconceptional exposure of mice to bisphenol A (BPA), either alone or in combination with X-irradiation. Males were exposed for 8 weeks to BPA, X-rays or both agents, and mated to unexposed females. Pre- and postnatal development of the offspring of exposed males was examined. Both BPA alone and the combined exposure slightly affected postnatal development. Combined exposure induced two-fold higher postnatal mortality than BPA the alone, whereas BPA exposure caused reduced body weight and diminished sperm quality in F1 generation.

Keywords: Bisphenol A; Combined exposure; Irradiation; Pre- and postnatal development; Reproduction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzhydryl Compounds / toxicity*
  • Body Weight / drug effects
  • Body Weight / radiation effects
  • Dose-Response Relationship, Drug
  • Estrogens, Non-Steroidal / toxicity
  • Female
  • Inheritance Patterns / drug effects
  • Inheritance Patterns / radiation effects
  • Male
  • Mice
  • Paternal Exposure*
  • Phenols / toxicity*
  • Spermatozoa / drug effects
  • Spermatozoa / radiation effects
  • X-Rays*

Substances

  • Benzhydryl Compounds
  • Estrogens, Non-Steroidal
  • Phenols
  • bisphenol A