Synergy of two human endogenous retroviruses in multiple myeloma

Kathrine L M Schmidt; Annette J Vangsted; Bettina Hansen; Ulla B Vogel; N Emil U Hermansen; Sara B Jensen; Magdalena J Laska; Bjørn A Nexø

doi:10.1016/j.leukres.2015.06.014

Synergy of two human endogenous retroviruses in multiple myeloma

Leuk Res. 2015 Oct;39(10):1125-8. doi: 10.1016/j.leukres.2015.06.014. Epub 2015 Jun 24.

Authors

Kathrine L M Schmidt¹, Annette J Vangsted², Bettina Hansen¹, Ulla B Vogel³, N Emil U Hermansen², Sara B Jensen¹, Magdalena J Laska¹, Bjørn A Nexø⁴

Affiliations

¹ Department of Biomedicin, Aarhus University, DK-8000 Aarhus C, Denmark.
² Department of Hematology, Rigshospitalet, Copenhagen University, DK-2100 Copenhagen, Denmark.
³ National Institute of Occupational Health, DK-2100 Copenhagen O, Denmark.
⁴ Department of Biomedicin, Aarhus University, DK-8000 Aarhus C, Denmark. Electronic address: nexo@biomed.au.dk.

PMID: 26231931
DOI: 10.1016/j.leukres.2015.06.014

Abstract

Multiple myeloma (MM) is a severe, incurable neoplasm of the plasma cells. In this study we have used genetic epidemiology to associate the risk of MM with endogenous retroviral loci in humans. We used SNP analysis on a Sequenom platform and statistical analysis in SPSS. Markers near two endogenous retroviral loci, HERV-Fc1 on chromosome X and HERV-K on chromosome 1, were associated with MM. Moreover, there was strong gene-gene interaction in relation to risk of MM. We take this as indirect confirmation of the association.

Keywords: Genetic epidemiology; Gene–gene interaction; HERV; Human endogenous retrovirus; Myelomatosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Endogenous Retroviruses / genetics*
Epistasis, Genetic
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Multiple Myeloma / genetics*
Multiple Myeloma / virology*
Polymorphism, Single Nucleotide