Regulation and function of the Salmonella MgtC virulence protein

J Microbiol. 2015 Oct;53(10):667-72. doi: 10.1007/s12275-015-5283-1. Epub 2015 Aug 1.

Abstract

Salmonella enterica serovar Typhimurium produces many virulence proteins to cause diseases. The Salmonella MgtC protein is one of such virulence proteins specially required for intracellular proliferation inside macrophages and mouse virulence. In this review, we will cover how the mgtC gene is turned on or off and what the signals required for mgtC expression are. Later in this review, we will discuss a recent understanding of MgtC function in Salmonella pathogenesis by identifying its target proteins.

Keywords: ATP homeostasis; Salmonella virulence; mgtC.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / biosynthesis
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism*
  • Cation Transport Proteins / biosynthesis
  • Cation Transport Proteins / genetics*
  • Cation Transport Proteins / metabolism*
  • Disease Models, Animal
  • Gene Expression Regulation, Bacterial*
  • Mice
  • Salmonella / genetics*
  • Salmonella / metabolism*
  • Salmonella / pathogenicity
  • Salmonella Infections / microbiology
  • Virulence / physiology
  • Virulence Factors / biosynthesis
  • Virulence Factors / genetics*
  • Virulence Factors / metabolism*

Substances

  • Bacterial Proteins
  • Cation Transport Proteins
  • Virulence Factors
  • MgtC protein, Salmonella typhimurium