X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

Wenpei Fan; Wenbo Bu; Zhen Zhang; Bo Shen; Hui Zhang; Qianjun He; Dalong Ni; Zhaowen Cui; Kuaile Zhao; Jiwen Bu; Jiulin Du; Jianan Liu; Jianlin Shi

doi:10.1002/anie.201504536

X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

Angew Chem Int Ed Engl. 2015 Nov 16;54(47):14026-30. doi: 10.1002/anie.201504536. Epub 2015 Jul 23.

Authors

Wenpei Fan¹, Wenbo Bu², Zhen Zhang³, Bo Shen⁴, Hui Zhang³, Qianjun He¹, Dalong Ni¹, Zhaowen Cui¹, Kuaile Zhao³, Jiwen Bu⁵, Jiulin Du⁵, Jianan Liu¹, Jianlin Shi⁶

Affiliations

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China).
² State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China). wbbu@mail.sic.ac.cn.
³ Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai, 200032 (P.R. China).
⁴ Institute of Radiation Medicine, Fudan University, Shanghai, 200032 (P.R. China).
⁵ State Key Laboratory of Neuroscience, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031 (P.R. China).
⁶ State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China). jlshi@mail.sic.ac.cn.

PMID: 26228648
DOI: 10.1002/anie.201504536

Abstract

Multifunctional stimuli-responsive nanotheranostic systems are highly desirable for realizing simultaneous biomedical imaging and on-demand therapy with minimized adverse effects. Herein, we present the construction of an intelligent X-ray-controlled NO-releasing upconversion nanotheranostic system (termed as PEG-USMSs-SNO) by engineering UCNPs with S-nitrosothiol (R-SNO)-grafted mesoporous silica. The PEG-USMSs-SNO is designed to respond sensitively to X-ray radiation for breaking down the S-N bond of SNO to release NO, which leads to X-ray dose-controlled NO release for on-demand hypoxic radiosensitization besides upconversion luminescent imaging through UCNPs in vitro and in vivo. Thanks to the high live-body permeability of X-ray, our developed PEG-USMSs-SNO may provide a new technique for achieving depth-independent controlled NO release and positioned radiotherapy enhancement against deep-seated solid tumors.

Keywords: NO release; X-ray radiation; hypoxic radiosensitization; luminescent imaging; on-demand therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Nanoparticles / chemistry*
Nanoparticles / radiation effects*
Nitric Oxide / chemistry*
Theranostic Nanomedicine / methods*
X-Rays*

Substances

Nitric Oxide