Molecular control of stress transmission in the microtubule cytoskeleton

Benjamin J Lopez; Megan T Valentine

doi:10.1016/j.bbamcr.2015.07.016

Molecular control of stress transmission in the microtubule cytoskeleton

Biochim Biophys Acta. 2015 Nov;1853(11 Pt B):3015-24. doi: 10.1016/j.bbamcr.2015.07.016. Epub 2015 Jul 28.

Authors

Benjamin J Lopez¹, Megan T Valentine²

Affiliations

¹ Department of Mechanical Engineering and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106-5070, USA.
² Department of Mechanical Engineering and Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106-5070, USA. Electronic address: valentine@engineering.ucsb.edu.

PMID: 26225932
DOI: 10.1016/j.bbamcr.2015.07.016

Abstract

In this article, we will summarize recent progress in understanding the mechanical origins of rigidity, strength, resiliency and stress transmission in the MT cytoskeleton using reconstituted networks formed from purified components. We focus on the role of network architecture, crosslinker compliance and dynamics, and molecular determinants of single filament elasticity, while highlighting open questions and future directions for this work.

Keywords: Elasticity; Microtubule-associated protein; Microtubules; Rheology.

Molecular control of stress transmission in the microtubule cytoskeleton

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