IPSCs, a Promising Tool to Restore Muscle Atrophy

J Cell Physiol. 2016 Feb;231(2):259-60. doi: 10.1002/jcp.25114.

Abstract

Induced pluripotent stem cells (iPSCs) are a promising tool for regenerative medicine in chronic conditions associated with muscle atrophy since iPSCs are easier to obtain, pose less ethical limitations and can better capture human genetic diversity compared with human embryonic stem cells. We highlight the potentiality of iPSCs for treating muscle-affecting conditions for which no effective cure is yet available, notably aging sarcopenia and inherited neurometabolic conditions. J. Cell. Physiol. 231: 259-260, 2016. © 2015 Wiley Periodicals, Inc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aging / pathology
  • Animals
  • Cell Differentiation
  • Humans
  • Induced Pluripotent Stem Cells / cytology
  • Induced Pluripotent Stem Cells / transplantation*
  • Mice
  • Muscular Atrophy / pathology
  • Muscular Atrophy / therapy*
  • Regenerative Medicine
  • Sarcopenia / pathology
  • Sarcopenia / therapy