Abstract
Four new lasiodiplodins (1-4), together with three known analogues, have been isolated from a mangrove endophytic fungus, Lasiodiplodia sp. 318#. Their structures were elucidated by spectroscopic techniques. Cytotoxic activities of compounds 1-7 were evaluated in vitro against human cancer lines THP1, MDA-MB-435, A549, HepG2 and HCT-116. Compound 4 exhibited moderate cytotoxic activities.
Keywords:
cytotoxic activity; endophytic fungus; lasiodiplodins.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemistry*
-
Antineoplastic Agents / isolation & purification
-
Ascomycota / chemistry*
-
Avicennia / microbiology*
-
Cell Line, Tumor
-
Endophytes / chemistry
-
Fermentation
-
Humans
-
Mitosporic Fungi
-
Molecular Structure
-
Zearalenone / analogs & derivatives*
-
Zearalenone / chemistry
-
Zearalenone / isolation & purification
Substances
-
Antineoplastic Agents
-
lasiodiplodin
-
Zearalenone