Complete withdrawal of hepatitis B virus prophylaxis after liver transplantation in a recipient at high risk of recurrence

Tian Shen; Yufu Ye; Lei Geng; Shusen Zheng

Complete withdrawal of hepatitis B virus prophylaxis after liver transplantation in a recipient at high risk of recurrence

Int J Clin Exp Med. 2015 May 15;8(5):8238-40. eCollection 2015.

Authors

Tian Shen¹, Yufu Ye¹, Lei Geng¹, Shusen Zheng¹

Affiliation

¹ Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University Zhejiang, China.

PMID: 26221402
PMCID: PMC4509347

Abstract

With the potent nucleos (t) ide analogues developed, necessity of life-long combined prophylaxis against hepatitis B virus (HBV) recurrence after HBV-related liver transplantation has been challenged. But complete withdrawal of HBV prophylaxis has not been previously observed in patients at high recurrence risk who showed active HBV replication before transplant. Herein, we describe a patient with positive HBeAg and HBV-DNA at the time of liver transplantation, who experienced complete HBV prophylaxis withdrawal after 3 years' application of hepatitis B immunoglobulin (HBIG) and entecavir, and showed no HBV recurrence during a long term of follow-up.

Keywords: Hepatitis B virus; entecavir; hepatitis B immunoglobulin; liver transplantation; prophylaxis; recurrence; withdrawal.

Publication types

Case Reports