Peripheral arterial disease in patients with giant cell arteritis: a meta-analysis

Patompong Ungprasert; Charat Thongprayoon; Wonngarm Kittanamongkolchai; Narat Srivali; Wisit Cheungpasitporn

doi:10.1111/1756-185X.12631

Peripheral arterial disease in patients with giant cell arteritis: a meta-analysis

Int J Rheum Dis. 2016 Aug;19(8):819-25. doi: 10.1111/1756-185X.12631. Epub 2015 Jul 28.

Authors

Patompong Ungprasert^{1

2}, Charat Thongprayoon³, Wonngarm Kittanamongkolchai³, Narat Srivali⁴, Wisit Cheungpasitporn³

Affiliations

¹ Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
² Department of medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
³ Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
⁴ Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

PMID: 26218931
DOI: 10.1111/1756-185X.12631

Abstract

Aim: To investigate the association between giant cell arteritis (GCA) and risk of peripheral arterial disease (PAD).

Methods: We conducted a systematic review and meta-analysis of observational cohort studies that reported relative risks, hazard ratios or standardized incidence ratios with 95% confidence comparing PAD risk in patients with GCA versus non-GCA subjects. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird.

Results: Four studies with 9789 patients with GCA and 236 728 controls were identified and included in our data analysis. The pooled risk ratio of PAD among patients with GCA compared with controls was 1.88 (95% CI 1.04-3.41). The statistical heterogeneity was high with an I(2) of 89%.

Conclusion: Our study demonstrated a statistically significant increased risk of PAD among patients with GCA.

Keywords: epidemiology; vasculitides (clinical aspects); vasculitides (general epidemiology studies).

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Case-Control Studies
Chi-Square Distribution
Giant Cell Arteritis / diagnosis
Giant Cell Arteritis / epidemiology*
Humans
Observational Studies as Topic
Odds Ratio
Peripheral Arterial Disease / diagnosis
Peripheral Arterial Disease / epidemiology*
Risk Factors