Myelination: actin disassembly leads the way

Jayshree Samanta; James L Salzer

doi:10.1016/j.devcel.2015.07.006

Myelination: actin disassembly leads the way

Dev Cell. 2015 Jul 27;34(2):129-30. doi: 10.1016/j.devcel.2015.07.006.

Authors

Jayshree Samanta¹, James L Salzer²

Affiliations

¹ New York University Neuroscience Institute, Departments of Physiology and Neuroscience, NYU School of Medicine, New York, NY 10016, USA.
² New York University Neuroscience Institute, Departments of Physiology and Neuroscience, NYU School of Medicine, New York, NY 10016, USA. Electronic address: james.salzer@nyumc.org.

Abstract

The mechanisms that drive the spiral wrapping of the myelin sheath around axons are poorly understood. Two papers in this issue of Developmental Cell demonstrate that actin disassembly, rather than actin assembly, predominates during oligodendrocyte maturation and is critical for the genesis of the central myelin sheath.

Publication types

Comment

MeSH terms

Actin Cytoskeleton / metabolism*
Actin-Related Protein 2-3 Complex / metabolism*
Animals
Central Nervous System / growth & development*
Myelin Sheath / physiology*
Oligodendroglia / physiology*

Substances

Actin-Related Protein 2-3 Complex

Grants and funding

R01 NS026001/NS/NINDS NIH HHS/United States