Sampling times influence the estimate of parameters in the Weibull dissolution model

Abstract

The aim is to determine how well the parameters of the Weibull model of dissolution can be estimated in dependency on the chosen times to measure the empirical data. The approach is based on the theory of Fisher information. We show that in order to obtain the best estimates the data should be collected at time instants when tablets actively dissolve or at their close proximity. This is in a sharp contrast with commonly used experimental protocols when sampling times are distributed rather uniformly.

Keywords: Dissolution; Fisher information; Optimal sampling times; Rate constant.