Abstract
Ultrasmall sub-5 nm KGdF4 rare earth nanoparticles were synthesized as multifunctional probes for fluorescent, magnetic, and radionuclide imaging. The cytotoxicity of these nanoparticles in human glioblastoma U87MG and human non-small cell lung carcinoma H1299 cells was evaluated, and their application for in vitro and in vivo tumor targeted imaging has also been demonstrated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacokinetics*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / toxicity*
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Cell Line, Tumor
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Cell Survival / drug effects*
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Humans
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Metals, Rare Earth / chemistry
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Metals, Rare Earth / toxicity*
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Mice
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Molecular Imaging
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Nanoparticles / chemistry
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Nanoparticles / toxicity*
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Neoplasms, Experimental / metabolism
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Positron-Emission Tomography
Substances
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Antineoplastic Agents
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Metals, Rare Earth